Severe suffering

General guidance

• Avoiding mortality in animal research and testing (2019)
   
• The RSPCA focus on severe suffering project (2016)
   
• A 'road map' toward ending severe suffering of animals used in research and testing (2014)
   
• Discussion paper: Reducing severe suffering (2013)
   
• Refinement - Lessons from the 2012 Olympics (2013)
   
• Focus on Severe Suffering Infographic (2020)

Specific procedures

• Refining rodent models of spinal cord injury (2020)
   
• Applying refinement to the use of mice and rats in rheumatoid arthritis research (2015)
   
• Refinement of animal models of sepsis and septic shock (2015, not open access)
   
• Reducing suffering in experimental autoimmune encephalomyelitis (EAE) (2013, not open access)
   
• Reducing suffering in animal models and procedures involving seizures, convulsions and epilepsy (2013, not open access)